Technology

Based on advanced brain science technology,
Ybrain​ is building an infrastructure to manage mental health more safely and easily.

The Future we Lead

Ybrain​, a mental-health electroceutical platform company, prepares for the future.
We are developing total health care solutions that include measurement, diagnosis, treatment, and management for patients with neuropsychiatric disorders, such as depression and dementia.
We have successfully commercialized the world's first hospital-home linked brain stimulation electroceutical platform, based on our company's patented technology related to non-invasive transcranial electrical stimulation (tES) and transcutaneous nerve stimulation (tNS) as well as on the at-home treatment management technologies, such as automatic control, treatment situation recognition, and misuse blocking.
In addition, we are currently building total solutions in order to provide a platform that measures patients' brain health and assists in diagnosis through the dry electrode-based multi-channel EEG measurement system and to enable the management of patients' brains and mental health based on the data. We also have developed a Brain-Computer Interface (BCI)-based neurofeedback system, which allows patients to train brain waves on their own based on the measured brain waves.

  • Brain disease electroceutical tES/tNS waveform output technology
  • Auto home treatment control, use authority, prevention of misuse
  • Data-based EEG symptom management platform technology
  • Micro band electroceutical device technology

Ybrain​ is an ecosystem suitable for home environments.
In other words, we are commercializing all the technology necessary for a mental healthcare platform.

Our Technology

Electroceutical

Electroceutical

electronics pharmaceuticals

Electroceutical is the core technology of Ybrain​, and we are not the most
commonly ingested or injected drug, but a method to control or treat the body's
metabolic functions using physical methods such as electrical stimulation, ultrasound, or light.

Commercial Mental Health Applications enabled
By Ybrain​'s Neurotechnology Solutions​

두팡 폴라 스팀 스캔 서베이 블루

두팡은 식약처 허가를 받은 편두통 완화 기기입니다.
TENS 기술을 사용한 두팡은 삼차신경에 미세한 전기 자극을 전달합니다.

  • Transcranial electrical stimulation (tES)

    tES is a non-invasive method of controlling nerve activity by delivering micro electrical stimulation to a specific part of the brain, which can be used to treat

    tES is a non-invasive method of controlling nerve

    mental illness, to enhance memory, and to improve learning ability. Ybrain​ is developing, researching, and commercializing various electrical waveforms, including direct current stimulation (tDCS), which is a representative type used for tES, alternating current stimulation (tACS), pulse current stimulation (tPCS), and random noise stimulation (tRNS).

    activity by delivering micro electrical stimulation to a specific part of the brain, which can be used to treat mental illness, to enhance memory, and to improve learning ability. Ybrain​ is developing, researching, and commercializing various electrical waveforms, including direct current stimulation (tDCS), which is a representative type used for tES, alternating current stimulation (tACS), pulse current stimulation (tPCS), and random noise stimulation (tRNS).

  • Transcranial Direct Current Stimulation (tDCS)

    As the most commonly used technology among tES, tDCS is a method of controlling nerve cell activity by applying a weak direct current to the brain

    As the most commonly used technology among tES,

    using two or more electrodes placed on the scalp.

    In tDCS technology, a positive (+, anode) sponge electrode and a negative (-, cathode) sponge electrode are attached to the scalp, and then DC current is generated and transmitted to the sponge electrodes. The microcurrent transmitted to the brain in this way regulates the activity of the cerebral cortex, stimulating and activating the brain. Through this action, the therapeutic effect can be obtained; thus, it is effectively used for improving cognitive ability and treating mental disorders, such as depression and ADHD.

    Ybrain​ succeeded in developing an at-home platform for transcranial electrical stimulation technology, and then successfully conducted an at-home clinical trial of the platform for the treatment of major depressive disorder and obtained approval for its marketing for the first time in the world. Currently, about 80 hospitals and clinics in South Korea (as of July 2023) are using tDCS for the purpose of improving depressive symptoms. In addition, a confirmatory clinical trial of tDCS is currently underway targeting patients with mild dementia and mild cognitive impairment.

    tDCS is a method of controlling nerve cell activity by applying a weak direct current to the brain using two or more electrodes placed on the scalp.

    In tDCS technology, a positive (+, anode) sponge electrode and a negative (-, cathode) sponge electrode are attached to the scalp, and then DC current is generated and transmitted to the sponge electrodes. The microcurrent transmitted to the brain in this way regulates the activity of the cerebral cortex, stimulating and activating the brain. Through this action, the therapeutic effect can be obtained; thus, it is effectively used for improving cognitive ability and treating mental disorders, such as depression and ADHD.

    Ybrain​ succeeded in developing an at-home platform for transcranial electrical stimulation technology, and then successfully conducted an at-home clinical trial of the platform for the treatment of major depressive disorder and obtained approval for its marketing for the first time in the world. Currently, about 80 hospitals and clinics in South Korea (as of July 2023) are using tDCS for the purpose of improving depressive symptoms. In addition, a confirmatory clinical trial of tDCS is currently underway targeting patients with mild dementia and mild cognitive impairment.

  • High-definition transcranial direct current stimulation (HD-tDCS)

    Since the conventional tDCS method uses two electrodes to evenly distribute the stimulation throughout the brain, it was difficult to apply stimulation

    Since the conventional tDCS method uses two

    intensively to a specific area. In contrast, multiple electrodes are used in HD-tDCS to deliver stimulation more specifically to the desired brain region. By using small and versatile electrodes, HD-tDCS can achieve precise targeting and focused current delivery to a specific area of the brain. This method enables more precise brain stimulation, and therefore more effective treatment outcomes can be expected.

    Ybrain​ has developed multi-channel HD-tDCS with 16 channels, completed its licensing, and is currently conducting clinical trials and research on patients with Parkinson's disease or stroke who require precise stimulation in the brain.

    electrodes to evenly distribute the stimulation throughout the brain, it was difficult to apply stimulation intensively to a specific area. In contrast, multiple electrodes are used in HD-tDCS to deliver stimulation more specifically to the desired brain region. By using small and versatile electrodes, HD-tDCS can achieve precise targeting and focused current delivery to a specific area of the brain. This method enables more precise brain stimulation, and therefore more effective treatment outcomes can be expected.

    Ybrain​ has developed multi-channel HD-tDCS with 16 channels, completed its licensing, and is currently conducting clinical trials and research on patients with Parkinson's disease or stroke who require precise stimulation in the brain.

  • Transcutaneous nerve stimulation (tNS / TENS)

    tNS is a technology that regulates nerve function through non-invasively and safely applied micro-electrical stimulation. When micro-electrical stimulation is

    tNS is a technology that regulates nerve function

    applied from a small device that is designed to be attached to body parts, such as the forehead and the neck, where major nerves pass through, it penetrates through the skin and reaches the nerve bundle.

    Weakly stimulated nerve cells control the activity of sympathetic nerves in the brain by modulating sensory nerve signals according to the type of stimulation applied. Through this action, tNS suppresses hyperarousal caused by internal and external stressors in the body to control stress disorders, insomnia, and anxiety symptoms, or to modulated various sensory abnormalities, such as migraine caused by overactivation of sensory nerves.

    Ybrain​ developed a new stimulation technology that combines pulse stimulation, burst stimulation, and DC stimulation for the first time in the world and acquired domestic and international patents. Also, we developed and commercialized a nerve stimulation device for the relief and prevention of migraine. Furthermore, we are seeking effectiveness in various indications, including improvement of insomnia.

    through non-invasively and safely applied micro-electrical stimulation. When micro-electrical stimulation is applied from a small device that is designed to be attached to body parts, such as the forehead and the neck, where major nerves pass through, it penetrates through the skin and reaches the nerve bundle.

    Weakly stimulated nerve cells control the activity of sympathetic nerves in the brain by modulating sensory nerve signals according to the type of stimulation applied. Through this action, tNS suppresses hyperarousal caused by internal and external stressors in the body to control stress disorders, insomnia, and anxiety symptoms, or to modulated various sensory abnormalities, such as migraine caused by overactivation of sensory nerves.

    Ybrain​ developed a new stimulation technology that combines pulse stimulation, burst stimulation, and DC stimulation for the first time in the world and acquired domestic and international patents. Also, we developed and commercialized a nerve stimulation device for the relief and prevention of migraine. Furthermore, we are seeking effectiveness in various indications, including improvement of insomnia.

  • EEG

    Electroencephalography (EEG) is a non-invasive technique for measuring the brain's electrical activity. Small electrodes attached to the scalp detect

    Electroencephalography (EEG) is a non-invasive

    electrical signals generated from the activity of neurons, which are nerve cells in the brain, and EEG amplifies and converts these signals. The location and number of sensors vary depending on the area to be measured or the purpose of the study. This technique is used in diverse fields, such as clinical diagnoses of brain damage, neurological disorders, and sleep disorders, research activities in cognitive science and neuroscience, brain activity monitoring, neural feedback training, and bio-signal interface.

    Ybrain​ provides convenience and portability by adopting dry electrodes, while also providing stable signal quality. A 19-channel EEG, to which neurofeedback is applied, our MINDD SCAN supports diagnosis and treatment of neurological diseases and brain injuries through brain activity monitoring and is also actively used as an evaluation tool in the medical research and clinical trials. In addition, we are actively promoting collaborative research with external companies and research institutions based on our experience in manufacturing devices with various numbers of channels.

    technique for measuring the brain's electrical activity. Small electrodes attached to the scalp detect electrical signals generated from the activity of neurons, which are nerve cells in the brain, and EEG amplifies and converts these signals. The location and number of sensors vary depending on the area to be measured or the purpose of the study. This technique is used in diverse fields, such as clinical diagnoses of brain damage, neurological disorders, and sleep disorders, research activities in cognitive science and neuroscience, brain activity monitoring, neural feedback training, and bio-signal interface.

    Ybrain​ provides convenience and portability by adopting dry electrodes, while also providing stable signal quality. A 19-channel EEG, to which neurofeedback is applied, our MINDD SCAN supports diagnosis and treatment of neurological diseases and brain injuries through brain activity monitoring and is also actively used as an evaluation tool in the medical research and clinical trials. In addition, we are actively promoting collaborative research with external companies and research institutions based on our experience in manufacturing devices with various numbers of channels.

  • HRV

    Heart rate variability (HRV) is derived by measuring and interpreting the variability in the consecutive pulse intervals of the heart. Normally, the pulse is not

    Heart rate variability (HRV) is derived by measuring

    regular, and the variability in the intervals between these heartbeats provides important information about the health condition and the activity of the autonomic nervous system. Data, collected using electrocardiogram (ECG) or photoplethysmogram (PPG), are analyzed in a variety of ways, including time and frequency domains. HRV analysis helps to evaluate healthy cardiovascular functions by comparing the difference in the heart rate variability between during the non-stress state and during the stress state, or by analyzing the difference between during daily activities and during sleep. It is also used to understand the balance and stress response of the autonomic nervous system, playing a significant role in medical examinations in the clinical setting as well as in the health management in the daily life.

    and interpreting the variability in the consecutive pulse intervals of the heart. Normally, the pulse is not regular, and the variability in the intervals between these heartbeats provides important information about the health condition and the activity of the autonomic nervous system. Data, collected using electrocardiogram (ECG) or photoplethysmogram (PPG), are analyzed in a variety of ways, including time and frequency domains. HRV analysis helps to evaluate healthy cardiovascular functions by comparing the difference in the heart rate variability between during the non-stress state and during the stress state, or by analyzing the difference between during daily activities and during sleep. It is also used to understand the balance and stress response of the autonomic nervous system, playing a significant role in medical examinations in the clinical setting as well as in the health management in the daily life.

  • Data survey

    MINDD is an online-based clinical scale delivery service that provides optimized services to medical and research institutions. In addition to the basic

    MINDD is an online-based clinical scale delivery

    psychiatric-based survey scale, various paid/free questionnaires can be uploaded and used, and the survey results can be checked on the platform in real time. It is also possible to create survey groups and to send out a list of questionnaires as desired with ease. The MINDD platform employs security technology and encryption to safely protect user data, and thus is being utilized to collect and analyze reliable data in various fields, such as medicine, life science, clinical research, and medical device evaluation.

    service that provides optimized services to medical and research institutions. In addition to the basic psychiatric-based survey scale, various paid/free questionnaires can be uploaded and used, and the survey results can be checked on the platform in real time. It is also possible to create survey groups and to send out a list of questionnaires as desired with ease. The MINDD platform employs security technology and encryption to safely protect user data, and thus is being utilized to collect and analyze reliable data in various fields, such as medicine, life science, clinical research, and medical device evaluation.

  • Electroceutical solution

    Ybrain​'s electroceutical solution, which has been verified by the MFDS in Korea, includes non-invasive waveform technology for cranial nerve electrical

    Ybrain​'s electroceutical solution, which has been

    stimulation and at-home treatment management technology, such as treatment situation recognition and misuse blocking.
    The electroceutical solution can be used for the treatment of various neuropsychiatric diseases and mental health management, such as improving depression, cognitive ability, and insomnia, and reducing stress. Due to its compact size, it can be easily installed in the existing medical devices, hardware, such as household appliances, and software services, such as digital healthcare.
    Through cooperative research with university hospitals located in Korea and overseas, we are seeking to expand the indications for our electroceutical solution, and we are also actively developing new electrical stimulation technologies, which include multi-channel and reusable electrodes and personalized electrical stimulation technology.

    verified by the MFDS in Korea, includes non-invasive waveform technology for cranial nerve electrical stimulation and at-home treatment management technology, such as treatment situation recognition and misuse blocking.
    The electroceutical solution can be used for the treatment of various neuropsychiatric diseases and mental health management, such as improving depression, cognitive ability, and insomnia, and reducing stress. Due to its compact size, it can be easily installed in the existing medical devices, hardware, such as household appliances, and software services, such as digital healthcare.
    Through cooperative research with university hospitals located in Korea and overseas, we are seeking to expand the indications for our electroceutical solution, and we are also actively developing new electrical stimulation technologies, which include multi-channel and reusable electrodes and personalized electrical stimulation technology.

  • Mental health management solution

    Ybrain​'s mental health management solution provides highly reliable mental health self-scale tests based on psychiatric and healthy people databases and

    Ybrain​'s mental health management solution provides

    the mental health monitoring function based on bio-signals, such as electroencephalogram (EEG) and heart rate variability (HRV).
    By analyzing questionnaires collected through a simple self-examination program, which was developed based on Ybrain​’s various clinical data and experiences of diseases affecting mental health, such as stress, anxiety, depression, and insomnia, which have been accumulated for 10 years, and bio-signal data using the AI-based analysis technology, we can provide the mental health indicators for the users. Based on the measured indicators, we provide an integrated mental health management solution using an electroceutical or digital treatment technology.
    We have been developing customized mental care platforms and solutions in collaboration with numerous global companies, research institutions, and government agencies; as a result, these platforms and solutions can be linked to the existing commercial services or new APPs/web services through collaborations. These platforms and solutions can also be used as technologies for the utilization of neuromarketing.

    highly reliable mental health self-scale tests based on psychiatric and healthy people databases and the mental health monitoring function based on bio-signals, such as electroencephalogram (EEG) and heart rate variability (HRV).
    By analyzing questionnaires collected through a simple self-examination program, which was developed based on Ybrain​’s various clinical data and experiences of diseases affecting mental health, such as stress, anxiety, depression, and insomnia, which have been accumulated for 10 years, and bio-signal data using the AI-based analysis technology, we can provide the mental health indicators for the users. Based on the measured indicators, we provide an integrated mental health management solution using an electroceutical or digital treatment technology.
    We have been developing customized mental care platforms and solutions in collaboration with numerous global companies, research institutions, and government agencies; as a result, these platforms and solutions can be linked to the existing commercial services or new APPs/web services through collaborations. These platforms and solutions can also be used as technologies for the utilization of neuromarketing.

  • Brain-computer interface (BCI) solution

    Ybrain​ provides a BCI solution based on the wireless, multi-channel, dry EEG measurement and analysis system. We developed commercial-level

    Ybrain​ provides a BCI solution based on the wireless,

    brain-machine interfaces to help quadriplegic patients move and mental health monitoring solutions that can be mounted on micro-electronic devices; they can be applied to digital device control and brain health monitoring using brain signals.
    By utilizing our own R&D and production systems, which include the patented dry electrode technology, we are developing platforms and interlocking technologies in the forms required by each institution through collaborations with global companies and research institutions.
    As a leading company in the field of neurotechnology, we have know-hows for development with various references, so we are capable of carrying out development and commercialization in conjunction with new types of platforms and services.

    multi-channel, dry EEG measurement and analysis system.
    We developed commercial-level brain-machine interfaces to help quadriplegic patients move and mental health monitoring solutions that can be mounted on micro-electronic devices; they can be applied to digital device control and brain health monitoring using brain signals.
    By utilizing our own R&D and production systems, which include the patented dry electrode technology, we are developing platforms and interlocking technologies in the forms required by each institution through collaborations with global companies and research institutions.
    As a leading company in the field of neurotechnology, we have know-hows for development with various references, so we are capable of carrying out development and commercialization in conjunction with new types of platforms and services.

  • R&D cases

    Actual example: Neurofeedback (Universal Brain) ​

    Actual example: Neurofeedback (Universal Brain)

    In collaboration with Universal Brain (Japan, USA), we are carrying out the full cycle of research, development, production, and application to patients for neurofeedback EEG devices to which dry electrodes are applied. Our goal is to provide patients with the best at-home care options through continuous improvement and innovation. To this end, we derive new designs, enhance the performance of devices based on research findings, and emphasize efficiency and quality in the production process. Lastly, in the stage of application to patients, we aim to have a positive impact on the actual medical field by providing a reliable treatment experience.

    In collaboration with Universal Brain (Japan, USA), we are carrying out the full cycle of research, development, production, and application to patients for neurofeedback EEG devices to which dry electrodes are applied. Our goal is to provide patients with the best at-home care options through continuous improvement and innovation. To this end, we derive new designs, enhance the performance of devices based on research findings, and emphasize efficiency and quality in the production process. Lastly, in the stage of application to patients, we aim to have a positive impact on the actual medical field by providing a reliable treatment experience.

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Pipeline & Timeline

This is a timeline guide for the technology development, the medium and long-term plans for the clinical pipeline, and the development status by each symptom/technology.

Credentials

Ybrain has numerous papers, and patents through continuous R&D and clinical activities.