Technology

Based on advanced brain science technology,
Ybrain is building an infrastructure to manage mental health more safely and easily.

The Future we Lead

Ybrain prepares for the future.
We have held the highest level of O2O platform, infrastructure technology,
and patents that allow a lot of patients to be treated at home at the same
time. Currently, we have commercialized the world's first hospital-home
linked brain stimulation platform, and our company's patented technology
related to SC/AC/RN and DC-Burster stimulation and dry electrodes supports
the treatment device, and automatic control, treatment situation recognition,
and misuse blocking patent technology supports the related platform technology.

  • Brain disease electroceutical tES/tNS waveform output technology
  • Auto home treatment control, use authority, prevention of misuse
  • Data-based EEG symptom management platform technology
  • Micro band electroceutical device technology

Ybrain is an ecosystem suitable for home environments.
In other words, we are commercializing all the technology necessary for a mental healthcare platform.

Our Technology

Electroceutical

Electroceutical

electronics pharmaceuticals

Electroceutical is the core technology of Ybrain, and we are not the most
commonly ingested or injected drug, but a method to control or treat the body's
metabolic functions using physical methods such as electrical stimulation, ultrasound, or light.

Commercial Mental Health Applications enabled
By Ybrain's Neurotechnology Solutions​

두팡은 식약처 허가를 받은 편두통 완화 기기입니다.
TENS 기술을 사용한 두팡은 삼차신경에 미세한 전기 자극을 전달합니다.

  • Brain stimulation

    Brain stimulation technology can be largely classified into invasive and non-invasive methods. Invasive methods representative is Deep Brain

    Brain stimulation technology can be largely classified into

    Stimulation (DBS) which is treated by electrodes inserted into the abnormal areas of the brain and direct application. A non-invasive method is a method of brain function control by the application of electrical stimulation or magnetic stimulation to the scalp.

    invasive and non-invasive methods. Invasive methods representative is Deep Brain Stimulation (DBS) which is treated by electrodes inserted into the abnormal areas of the brain and direct application. A non-invasive method is a method of brain function control by the application of electrical stimulation or magnetic stimulation to the scalp.

  • tES / transcranial Electrical Stimulation

    This is a technology that controls brain function through non-invasive and safely applied micro electrical stimulation. About 20 to 40 percent

    This is a technology that controls brain function

    of the micro electrical stimulation applied to the scalp through a small device worn on the forehead passes through the skull to reach the cerebral cortex. Fine stimulated neurons regulate the membrane potential in the rest state, voluntary activity increasing, through this way, it controls the abnormal activity of the left and right Dorsolateral Prefrontal Cortex in major depression disorders or dementia.

    through non-invasive and safely applied micro electrical stimulation. About 20 to 40 percent of the micro electrical stimulation applied to the scalp through a small device worn on the forehead passes through the skull to reach the cerebral cortex. Fine stimulated neurons regulate the membrane potential in the rest state, voluntary activity increasing, through this way, it controls the abnormal activity of the left and right Dorsolateral Prefrontal Cortex in major depression disorders or dementia.

  • tDCS Transcranial Direct Current Stimulation

    tDCS refers to a technology that changes the excitability and activity of the cerebral cortex by the direction of current through the nerve

    tDCS refers to a technology that changes the excitability

    by controlling the voltage threshold below the neuronal membrane potential (Purura and McMurry, 1965). tDCS is one of the Transcranial electric stimulus techniques that apply weak direct current to the scalp through two or more electrodes placed on the scalp. The action principle of the Ybrain tDCS technology is that a cathode (+, Anode) sponge electrode and an anode (-, Cathode) sponge electrode wetted in a saline solution are attached to the scalp, and a direct current is generated to be transferred to the sponge electrode. Then, the cerebral cortex with minute bipolar (+,-) current is synchronized with the electric current delivered to the electrode and the membrane potential difference, which causes a special excited state of the motor cortex. Through this action, the brain can be stimulated and activated to get the treatment effects. Brain electrical stimulation technology by using tDCS is known to be effective in cognitive ability improvement, mental treatment of disorders such as depression, ADHD, and others. Ybrain has succeeded in developing the most advanced platform in transdermal electrical stimulation technology and succeeding in the world's first home clinical trial and sales license for major depressive disorders home clinical trial, and the ongoing clinical trial for mild dementia is scheduled to end in 2022.

    and activity of the cerebral cortex by the direction of current through the nerve by controlling the voltage threshold below the neuronal membrane potential (Purura and McMurry, 1965). tDCS is one of the Transcranial electric stimulus techniques that apply weak direct current to the scalp through two or more electrodes placed on the scalp. The action principle of the Ybrain tDCS technology is that a cathode (+, Anode) sponge electrode and an anode (-, Cathode) sponge electrode wetted in a saline solution are attached to the scalp, and a direct current is generated to be transferred to the sponge electrode. Then, the cerebral cortex with minute bipolar (+,-) current is synchronized with the electric current delivered to the electrode and the membrane potential difference, which causes a special excited state of the motor cortex. Through this action, the brain can be stimulated and activated to get the treatment effects. Brain electrical stimulation technology by using tDCS is known to be effective in cognitive ability improvement, mental treatment of disorders such as depression, ADHD, and others. Ybrain has succeeded in developing the most advanced platform in transdermal electrical stimulation technology and succeeding in the world's first home clinical trial and sales license for major depressive disorders home clinical trial, and the ongoing clinical trial for mild dementia is scheduled to end in 2022.

    뇌파지표의 Z-SCORE 변환

  • TENS Non-invasive transcutaneous nerve stimulation technology

    This is a technology that controls nerve function through non-invasive and safely certified micro-electrical stimulation. Through this, it suppresses

    This is a technology that controls nerve function

    hyperarousal phenomena caused by internal and external stressors in the body to control stress disorders, insomnia, and anxiety symptoms, or to control various sensory abnormalities such as migraine and others caused by overactivities of sensory nerves. Ybrain developed the world's first new stimulation technology that mixed burst stimulation and DC stimulation in the kHz region, and gotten domestic and foreign patents, and is seeking effectiveness in various indications.

    through non-invasive and safely certified micro-electrical stimulation. Through this, it suppresses hyperarousal phenomena caused by internal and external stressors in the body to control stress disorders, insomnia, and anxiety symptoms, or to control various sensory abnormalities such as migraine and others caused by overactivities of sensory nerves. Ybrain developed the world's first new stimulation technology that mixed burst stimulation and DC stimulation in the kHz region, and gotten domestic and foreign patents, and is seeking effectiveness in various indications.

    뇌파지표의 Z-SCORE 변환

  • transcutaneous Nerve Stimulation(tNS)

    Various attempts are done to treat patients' medical diseases by electrical stimulation

    Various attempts are done to treat patients' medical

    applied to the nerves, and tNS is a non-invasive method of electrical stimulation applied to the epidermis to be reached the nerves. Non-invasive methods have far superior merits in risk and safety compared to invasive methods.

    diseases by electrical stimulation applied to the nerves, and tNS is a non-invasive method of electrical stimulation applied to the epidermis to be reached the nerves. Non-invasive methods have far superior merits in risk and safety compared to invasive methods.

    뇌파지표의 Z-SCORE 변환

  • EEG (Electroencephalogram, brain waves)

    EEG refers to an electrophysiological measurement method to records

    EEG refers to an electrophysiological

    the electrical activity of the brain through electrodes. This is a technology that measures the brain neurons' activity in real-time safely and non-invasive. On wearing a small device that covers the head, about 20 to 64 microelectrodes contacting the scalp measure the signal (Electroencephalogram) in uV units that passed through the skull among micro-electrical signals generated by cranial nerve cell activity. The measured electroencephalogram is amplified in several steps and converted into computer-readable digital signals, and provides information on functional abnormalities, consciousness level, metabolic disorders, seizures, and other nonorganic diseases compared to normal person brain nerve cell activity data. Ybrain has commercialized the most advanced digital EEG medical devices in industries and automatic analysis systems and is upgrading technologies in the areas of neuropsychiatry and brain diagnostic assistance, dementia diagnosis, and examination, and the monitoring of sleep and stress.

    measurement method to records the electrical activity of the brain through electrodes. This is a technology that measures the brain neurons' activity in real-time safely and non-invasive. On wearing a small device that covers the head, about 20 to 64 microelectrodes contacting the scalp measure the signal (Electroencephalogram) in uV units that passed through the skull among micro-electrical signals generated by cranial nerve cell activity. The measured electroencephalogram is amplified in several steps and converted into computer-readable digital signals, and provides information on functional abnormalities, consciousness level, metabolic disorders, seizures, and other nonorganic diseases compared to normal person brain nerve cell activity data. Ybrain has commercialized the most advanced digital EEG medical devices in industries and automatic analysis systems and is upgrading technologies in the areas of neuropsychiatry and brain diagnostic assistance, dementia diagnosis, and examination, and the monitoring of sleep and stress.

    뇌파지표의 Z-SCORE 변환

  • qEEG(Quantitative EEG : Quantitative electroencephalogram)

    This is data that measures/analyzes various brain waves acting on the brain and shows

    This is data that measures/analyzes various

    as numbers and pictures to know easily. Quantitative EEG is a digitized EEG analysis and is known as brain mapping. In other words, it can be an extended concept for the analysis of visual EEG analysis that can enhance understanding of brain waves and brain function. Such quantitative EEG can evaluate brain function and can be used and interpreted by experts as a clinical tool for changes trace in brain function by neurofeedback, etc.

    brain waves acting on the brain and shows as numbers and pictures to know easily. Quantitative EEG is a digitized EEG analysis and is known as brain mapping. In other words, it can be an extended concept for the analysis of visual EEG analysis that can enhance understanding of brain waves and brain function. Such quantitative EEG can evaluate brain function and can be used and interpreted by experts as a clinical tool for changes trace in brain function by neurofeedback, etc.

    Analysis and Interpretation Methods

    1. Analysis: Deduction of quantitative EEG indicators after noise removal

    2. Interpretation: Abnormal EEG identification based on z-score by comparing NormDB

    뇌파지표의 Z-SCORE 변환

  • HR (Heart Rate : Heart Rate)

    Heart rate refers to the heart rate per unit time (usually for 1 minute) and is consistent with the pulse rate (bpm) usually felt in the radial camellia.

    Heart rate refers to the heart rate per unit time

    Generally, the number of R-R peak values during a minute in ECG means heart rate. It can be divided into stable heart rate and maximum heart rate. A lower heart rate means that the heart can pump more blood into the body at one time. Maximum heart rate is the highest heart rate your heart can beat in one minute, and it is your heart rate when performing an exercise at maximum strength.

    (usually for 1 minute) and is consistent with the pulse rate (bpm) usually felt in the radial camellia. Generally, the number of R-R peak values during a minute in ECG means heart rate. It can be divided into stable heart rate and maximum heart rate. A lower heart rate means that the heart can pump more blood into the body at one time. Maximum heart rate is the highest heart rate your heart can beat in one minute, and it is your heart rate when performing an exercise at maximum strength.

  • ECG (Electrocardiogram)

    An electrocardiogram refers to the electrical activity analysis

    An electrocardiogram refers to the electrical

    of the heart and recording it in the form of waves. Myocardial cells contract and relax in response to an electrical current, and these activities are controlled by the current flowing through the heart's conduction system. So, by analyzing the heart's electrical activity, you can tell what's going on with the heart. Usually, the number of R-R peak values per minute, which means the highest ECG value, corresponds to the heart rate.

    activity analysis of the heart and recording it in the form of waves. Myocardial cells contract and relax in response to an electrical current, and these activities are controlled by the current flowing through the heart's conduction system. So, by analyzing the heart's electrical activity, you can tell what's going on with the heart. Usually, the number of R-R peak values per minute, which means the highest ECG value, corresponds to the heart rate.

  • HRV (Heart Rate Variability)

    The human heart is beating every moment but does not work in a regular pattern.

    The human heart is beating every moment but

    Every moment, depending on the situation changes minutely. Heart rate variability is a number quantified by the temporal fluctuations measurement of the cardiac cycle. That is, the heart rate variability does not mean a heart rate change, but is quantified by the temporal fluctuation measurement of the R-value on the electrocardiogram, which is the reference value of the heart rate.
    Heart rate variability is generally regulated by the sympathetic and parasympathetic nerve, and heart rate variability is related overall to autonomic nervous system activity. By measuring and analyzing the periodic change of cardiac impulse over time, we can get information about the physiological response in various situations and quantify the activity of the autonomic nervous system.

    does not work in a regular pattern.
    Every moment, depending on the situation changes minutely. Heart rate variability is a number quantified by the temporal fluctuations measurement of the cardiac cycle. That is, the heart rate variability does not mean a heart rate change, but is quantified by the temporal fluctuation measurement of the R-value on the electrocardiogram, which is the reference value of the heart rate.
    Heart rate variability is generally regulated by the sympathetic and parasympathetic nerve, and heart rate variability is related overall to autonomic nervous system activity. By measuring and analyzing the periodic change of cardiac impulse over time, we can get information about the physiological response in various situations and quantify the activity of the autonomic nervous system.

    뇌파지표의 Z-SCORE 변환

    뇌파지표의 Z-SCORE 변환

  • Treatment / Prevention

    Depression / Cognitive Dysfunction / Insomnia / Addiction / Etc

    Depression / Cognitive Dysfunction

    As Ybrain Electroceutical Solution is the verified smallest solution by the approval of MFDS Korea/ FDA, it can be used for treatment/ prevention of various neuropsychiatric diseases which is installed easily on the software service such as existing medical devices, home appliances, digital health care, etc.

    / Insomnia / Addiction / Etc​
    As Ybrain Electroceutical Solution is the verified smallest solution by the approval of MFDS Korea/ FDA, it can be used for treatment/ prevention of various neuropsychiatric diseases which is installed easily on the software service such as existing medical devices, home appliances, digital health care, etc.

  • Patient management

    Electroencephalography / Heart-rate Variability / Activity or Sleep Tracking / Self-Questionnaire​

    Electroencephalography /

    Ybrain patient Solution is easy to do the Web/App service system link for the existing treatment device or treatment/management which provides the patient monitoring function and high reliable diagnosis assistance based on the psychiatry database.

    Heart-rate Variability / Activity or Sleep Tracking / Self-Questionnaire​
    Ybrain patient Solution is easy to do the Web/App service system link for the existing treatment device or treatment/management which provides the patient monitoring function and high reliable diagnosis assistance based on the psychiatry database.

  • Enhancement

    Stress Response / Attention / Cognition / Motor Response / Etc​

    Stress Response / Attention / Cognition /

    Ybrain brain function improvement solution can be easily installed on the system link to the health care service of the function such as immediate stress suppression, attention improvement, etc with the micro personal device of the patented proprietary technology.

    Motor Response / Etc​
    Ybrain brain function improvement solution can be easily installed on the system link to the health care service of the function such as immediate stress suppression, attention improvement, etc with the micro personal device of the patented proprietary technology.

  • Mental health management

    Electroencephalography / Heart-rate Variability / Activity or Sleep Tracking / Self-Questionnaire​

    Electroencephalography /

    Ybrain mental health management solution provides a highly reliable mental health self-check and condition monitoring function based on psychiatry and health person’s database. It can easily be linked to a new Web/App service or the existing routine service of partner companies.

    Heart-rate Variability / Activity or Sleep Tracking / Self-Questionnaire​
    Ybrain mental health management solution provides a highly reliable mental health self-check and condition monitoring function based on psychiatry and health person’s database. It can easily be linked to a new Web/App service or the existing routine service of partner companies.

  • Brain Computer Interface

    Non-invasive Mobility Interface Device for Quadriplegia / Miniaturized Mental Tracking Device for Healthy

    Non-invasive Mobility Interface

    Ybrain has developed firstly in Korea the movable brain machine interface for quadriplegia patient of routine level and metal monitoring solution for micro electric device installation. The development know-how to lead the industry makes it possible to fast application product development on the new area.

    Device for Quadriplegia / Miniaturized Mental Tracking Device for Healthy​
    Ybrain has developed firstly in Korea the movable brain machine interface for quadriplegia patient of routine level and metal monitoring solution for micro electric device installation. The development know-how to lead the industry makes it possible to fast application product development on the new area.

  • Special Applications

    Military / Space / Education​

    Military / Space / Education

    Ybrain has created new cases of the monitoring solution and the brain function of special areas such as National Defense, Space, Education, etc.

    Ybrain has created new cases of the monitoring solution and the brain function of special areas such as National Defense, Space, Education, etc.

Contact Us

Pipeline & Timeline

This is a timeline guide for the technology development, the medium and long-term plans for the clinical pipeline, and the development status by each symptom/technology.

Certificates

YBrain has numerous papers, and patents through continuous R&D and clinical activities.

  • T

    Papers

    Effect of Self-administered Transcranial Direct Stimulation in Patients with Major Depressive Disorder: A Randomized, Single-blinded Clinical Trial

    Clinical Psychopharmacology and Neuroscience

    2022.02.01

  • T

    Papers

    The Effects of tDCS with NDT on the Improvement of Motor Development in Cerebral Palsy

    Journal of Motor Behavior

    2021.12.16

  • T

    Papers

    tACS as a promising therapeutic option for improving cognitive function in mild cognitive impairment: A direct comparison between tACS and tDCS

    Journal of Psychiatric Research

    2021.07.05

  • T

    Papers

    Impact of Transcranial Direct Current Stimulation on Cognitive Function, Brain Functional Segregation, and Integration in Patients with Mild Cognitive Impairment According to Amyloid-Beta Deposition and APOE ε4-Allele: A Pilot Study

    brain science

    2021.06.10